Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 8/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827302 | 0.90 | TSHR (0.46) | TSHRSMN1; SMN2MAPK1USP2NPSR1 | |
| SCHEMBL2828495 | 0.87 | KDM4E (0.51) | TSHRSMN1; SMN2MAPK1USP2NPSR1 | |
| SCHEMBL14237377 | 0.85 | TSHR (0.45) | TSHRSMN1; SMN2MAPK1USP2NPSR1 | |
| SCHEMBL2830427 | 0.83 | TSHR (0.50) | TSHRSMN1; SMN2MAPK1USP2NPSR1 | |
| SCHEMBL3079579 | 0.82 | TSHR (0.51) | TSHRSMN1; SMN2MAPK1USP2NPSR1 | |
| SCHEMBL2826380 | 0.81 | SMN1; SMN2 (0.67) | TSHRSMN1; SMN2MAPK1USP2NPSR1 | |
| SCHEMBL3262775 | 0.81 | TSHR (0.49) | TSHRSMN1; SMN2MAPK1USP2NPSR1 | |
| SCHEMBL2830271 | 0.81 | TSHR (0.56) | TSHRSMN1; SMN2MAPK1USP2NPSR1 | |
| SCHEMBL2829861 | 0.80 | SMN1; SMN2 (0.65) | TSHRSMN1; SMN2MAPK1USP2NPSR1 | |
| SCHEMBL2829525 | 0.80 | TSHR (0.61) | TSHRSMN1; SMN2MAPK1USP2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168578-B1 | Thiazole based inhibitors of ATP-utilizing enzymes | GENENTECH INC (US) | 2012-12-19 | — | — | EP | claimed |