Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.47 |
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237389 | 0.93 | SMN1; SMN2 (0.43) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 | |
| SCHEMBL2830432 | 0.88 | SMN1; SMN2 (0.47) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 | |
| SCHEMBL2826835 | 0.86 | SMN1; SMN2 (0.55) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 | |
| SCHEMBL2824848 | 0.86 | SMN1; SMN2 (0.49) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 | |
| SCHEMBL2831404 | 0.86 | SMN1; SMN2 (0.47) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 | |
| SCHEMBL2830235 | 0.86 | SMN1; SMN2 (0.47) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 | |
| SCHEMBL2826734 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 | |
| SCHEMBL2832452 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 | |
| SCHEMBL2830920 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 | |
| SCHEMBL2826927 | 0.83 | SMN1; SMN2 (0.46) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168578-B1 | Thiazole based inhibitors of ATP-utilizing enzymes | GENENTECH INC (US) | 2012-12-19 | — | — | EP | claimed |