Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.40 |
| ▸ | DPP4 | P27487 | 3/20 | 0.40 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | EIF4E | P06730 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21223469 | 0.88 | SCN10A (0.46) | BACE1SCN10ADPP4ABL1NPC1 | |
| SCHEMBL263262 | 0.82 | SCN10A (0.56) | BACE1SCN10ANPC1MEN1MAPT | |
| SCHEMBL29495966 | 0.81 | DPP4 (0.42) | BACE1DPP4ABL1NPC1EIF4E | |
| SCHEMBL28722134 | 0.81 | DPP4 (0.42) | BACE1DPP4ABL1NPC1EIF4E | |
| SCHEMBL1388306 | 0.78 | AHR (0.48) | BACE1SCN10ANPC1MEN1MAPT | |
| SCHEMBL263442 | 0.76 | SCN10A (0.58) | SCN10ADPP4NPC1EIF4EMEN1 | |
| SCHEMBL14237492 | 0.75 | FFAR4 (0.44) | SCN10ANPC1EIF4EMAPTRAB9A | |
| SCHEMBL263446 | 0.74 | NPC1 (0.51) | BACE1SCN10ADPP4NPC1MEN1 | |
| SCHEMBL29496134 | 0.74 | NPC1 (0.51) | BACE1SCN10ADPP4NPC1MEN1 | |
| SCHEMBL27776395 | 0.74 | AHR (0.41) | BACE1SCN10ANPC1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183241-B1 | 2-PYRIDINE CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS | PFIZER LTD (GB) | 2012-12-19 | — | — | EP | disclosed |
| CN-101675040-A | 2-pyridinecarboxamide derivatives as sodium channel modulators | PFIZER LTD | 2010-03-17 | — | — | CN | disclosed |