Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 8/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CDK2AP1 | O14519 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3461876 | 0.85 | ATR (0.46) | ATRTYRO3PRKDCCCNE2CCNE1 | |
| SCHEMBL3460952 | 0.85 | ATR (0.45) | ATRTYRO3AXLMERTKPRKDC | |
| SCHEMBL3460685 | 0.83 | ACVR1 (0.50) | ATRTYRO3ACVR1CCNE2CCNE1 | |
| SCHEMBL3460004 | 0.81 | TYRO3 (0.53) | ATRTYRO3PRKDCACVR1CDK2AP1 | |
| SCHEMBL3460859 | 0.79 | TYRO3 (0.52) | ATRTYRO3PRKDCACVR1CDK2AP1 | |
| SCHEMBL3459733 | 0.78 | TYRO3 (0.55) | ATRTYRO3PRKDCACVR1CDK2AP1 | |
| SCHEMBL14237322 | 0.78 | ATR (0.46) | ATRTYRO3HTR7PRKDCCCNE2 | |
| SCHEMBL3462056 | 0.77 | CHEK1 (0.62) | ATRTYRO3PRKDCACVR1CDK2AP1 | |
| SCHEMBL3460835 | 0.77 | TYRO3 (0.65) | ATRTYRO3PRKDCACVR1CHEK1 | |
| SCHEMBL3459906 | 0.76 | TYRO3 (0.55) | ATRTYRO3ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-B1 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2012-12-19 | — | — | EP | claimed |