Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 12/20 | 0.68 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.68 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.68 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.68 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.68 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237594 | 0.90 | SCN10A (0.57) | SCN10ASCN5ASCN9ASCN2ASCN3A | |
| SCHEMBL14237332 | 0.87 | SCN10A (0.72) | SCN10ASCN5ASCN9ASCN2ASCN3A | |
| SCHEMBL14237618 | 0.86 | SCN10A (0.71) | SCN10ASCN5ASCN9ASCN2ASCN3A | |
| SCHEMBL264140 | 0.84 | SCN10A (0.78) | SCN10ASCN5ASCN9ASCN2ASCN3A | |
| SCHEMBL262908 | 0.83 | SCN10A (0.76) | SCN10ASCN5ASCN9ASCN2ASCN3A | |
| SCHEMBL14237569 | 0.81 | SCN10A (0.67) | SCN10ASCN5ASCN9ASCN2ASCN3A | |
| SCHEMBL262780 | 0.81 | SCN10A (1.00) | SCN10ASCN5ASCN9ASCN2ASCN3A | |
| SCHEMBL14237294 | 0.80 | SCN10A (0.69) | SCN10ASCN5ASCN9ASCN2ASCN3A | |
| SCHEMBL14237619 | 0.80 | SCN10A (0.66) | SCN10ASCN5ASCN9ASCN2ASCN3A | |
| SCHEMBL263424 | 0.78 | SCN10A (0.73) | SCN10ASCN5ASCN9ASCN2ASCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183241-B1 | 2-PYRIDINE CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS | PFIZER LTD (GB) | 2012-12-19 | — | — | EP | disclosed |