Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 13/20 | 0.81 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.57 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.57 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.57 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.57 |
| ▸ | SCN1A | P35498 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL263118 | 0.90 | SCN10A (1.00) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL263548 | 0.88 | SCN10A (1.00) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL14237710 | 0.87 | SCN10A (0.83) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL262885 | 0.85 | SCN10A (0.79) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL14237505 | 0.84 | SCN10A (0.58) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL14237757 | 0.82 | SCN10A (0.82) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL264597 | 0.81 | SCN10A (0.81) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL14237554 | 0.81 | SCN10A (0.80) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL263424 | 0.81 | SCN10A (0.73) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL264547 | 0.81 | SCN10A (0.80) | SCN10ASCN9ASCN5ASCN2ASCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183241-B1 | 2-PYRIDINE CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS | PFIZER LTD (GB) | 2012-12-19 | — | — | EP | disclosed |