Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 14/20 | 0.63 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.63 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.63 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.63 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.63 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 4/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237608 | 0.91 | SCN10A (0.67) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL263117 | 0.89 | SCN10A (0.76) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL262490 | 0.87 | SCN10A (0.65) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL14237596 | 0.87 | SCN10A (0.65) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL14237435 | 0.85 | SCN10A (0.64) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL14237465 | 0.85 | SCN10A (0.62) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL264423 | 0.85 | SCN10A (0.62) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL263316 | 0.85 | SCN10A (0.81) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL262879 | 0.83 | SCN10A (0.60) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL263586 | 0.83 | SCN10A (0.60) | SCN10ASCN9ASCN5ASCN2ASCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183241-B1 | 2-PYRIDINE CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS | PFIZER LTD (GB) | 2012-12-19 | — | — | EP | disclosed |