Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 10/20 | 0.57 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237438 | 0.88 | SCN10A (0.59) | SCN10ASCN5ASCN9ASCN1AL3MBTL1 | |
| SCHEMBL14237511 | 0.87 | SCN10A (0.74) | SCN10ASCN5ASCN9ASCN1AL3MBTL1 | |
| SCHEMBL265170 | 0.86 | SCN10A (0.77) | SCN10ASCN5ASCN9ASCN1AL3MBTL1 | |
| SCHEMBL263600 | 0.86 | SCN10A (0.78) | SCN10ASCN5ASCN9ASCN1AL3MBTL1 | |
| SCHEMBL14237482 | 0.82 | SCN10A (0.59) | SCN10ASCN5ASCN9ASCN1AL3MBTL1 | |
| SCHEMBL14237601 | 0.79 | SCN10A (0.78) | SCN10ASCN5ASCN9ASCN1AL3MBTL1 | |
| SCHEMBL264146 | 0.78 | SCN10A (0.68) | SCN10ASCN5ASCN9ASCN1AL3MBTL1 | |
| SCHEMBL14237298 | 0.78 | SCN10A (0.78) | SCN10ASCN5ASCN9ASCN1ASCN2A | |
| SCHEMBL14237453 | 0.78 | SCN10A (0.64) | SCN10ASCN5ASCN9ASCN1ASCN2A | |
| SCHEMBL14237373 | 0.78 | SCN10A (0.54) | SCN10ASCN5ASCN9ASCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183241-B1 | 2-PYRIDINE CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS | PFIZER LTD (GB) | 2012-12-19 | — | — | EP | disclosed |