Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.48 |
| ▸ | COMT | P21964 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2750134 | 0.88 | PDE10A (0.53) | PDE10AALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2751557 | 0.88 | PDE10A (0.51) | PDE10AALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2749888 | 0.88 | PDE10A (0.53) | PDE10AALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2749776 | 0.87 | PDE10A (0.51) | PDE10AALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14237640 | 0.87 | PDE10A (0.49) | PDE10AALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2496050 | 0.86 | PDE10A (0.56) | PDE10AALDH1A1SMN1; SMN2KMT2AKDM4E | |
| SCHEMBL2750931 | 0.85 | PDE10A (0.56) | PDE10AALDH1A1SMN1; SMN2KMT2ANPSR1 | |
| SCHEMBL2504022 | 0.82 | PDE10A (0.58) | PDE10AALDH1A1SMN1; SMN2KMT2AKDM4E | |
| SCHEMBL2499998 | 0.82 | PDE10A (0.45) | PDE10AALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2503796 | 0.81 | PDE10A (0.59) | PDE10AALDH1A1SMN1; SMN2KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373641-B1 | PYRIDAZINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-12-19 | — | — | EP | claimed |