Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.62 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237790 | 0.92 | PDE10A (0.68) | PDE10ATRPV4CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14237630 | 0.91 | PDE10A (0.61) | PDE10ATRPV4CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14237727 | 0.89 | PDE10A (0.56) | PDE10ATRPV4CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14237718 | 0.88 | PDE10A (0.60) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14237738 | 0.87 | PDE10A (0.64) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2493463 | 0.87 | PDE10A (0.81) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2750667 | 0.85 | PDE10A (0.64) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2749464 | 0.84 | PDE10A (0.71) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14237496 | 0.83 | PDE10A (0.53) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14237641 | 0.83 | CYP1A2 (0.58) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373641-B1 | PYRIDAZINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-12-19 | — | — | EP | claimed |