Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 13/20 | 0.61 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.52 |
| ▸ | SCN1A | P35498 | 2/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.52 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.50 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237413 | 0.88 | SCN10A (0.74) | SCN10ASCN9ASCN1ASCN5ASCN2A | |
| SCHEMBL263363 | 0.86 | SCN10A (0.81) | SCN10ASCN9ASCN1ASCN5ASCN2A | |
| SCHEMBL14237556 | 0.85 | SCN10A (0.61) | SCN10ASCN9ASCN1ASCN5ASCN2A | |
| SCHEMBL14237636 | 0.82 | SCN10A (0.63) | SCN10ASCN9ASCN1ASCN5ASCN2A | |
| SCHEMBL14237524 | 0.82 | SCN10A (0.76) | SCN10ASCN9ASCN1ASCN5ASCN2A | |
| SCHEMBL14237427 | 0.80 | SCN10A (0.64) | SCN10ASCN9ASCN1ASCN5ASCN2A | |
| SCHEMBL14237701 | 0.80 | SCN10A (0.72) | SCN10ASCN9ASCN1ASCN5ASCN2A | |
| SCHEMBL262885 | 0.78 | SCN10A (0.79) | SCN10ASCN9ASCN1ASCN5ASCN2A | |
| SCHEMBL14237513 | 0.77 | SCN10A (0.64) | SCN10ASCN9ASCN1ASCN5ASCN2A | |
| SCHEMBL263242 | 0.77 | SCN10A (0.55) | SCN10ASCN9ASCN1ASCN5ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183241-B1 | 2-PYRIDINE CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS | PFIZER LTD (GB) | 2012-12-19 | — | — | EP | disclosed |