Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | FYN | P06241 | 8/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.47 |
| ▸ | PIM1 | P11309 | 2/20 | 0.47 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1424116 | 0.86 | FYN (0.70) | PIK3CGMAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL4338374 | 0.86 | PIK3CG (0.71) | PIK3CGMAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL4594891 | 0.86 | PIK3CG (0.84) | PIK3CGMAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL4333167 | 0.85 | PIK3CG (0.64) | PIK3CGMAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL4558600 | 0.84 | FYN (0.74) | PIK3CGMAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL4333705 | 0.82 | PIK3CG (0.57) | PIK3CGMAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL4333475 | 0.82 | PIK3CG (0.61) | PIK3CGMAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL4594592 | 0.80 | FYN (0.74) | PIK3CGMAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL14302657 | 0.80 | FYN (0.76) | PIK3CGMAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL4595051 | 0.79 | PIK3CG (0.70) | PIK3CGMAPTSMN1; SMN2LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081933-B1 | PYRAZOLOPYRIMIDINES AS PI3K LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-03-23 | — | — | EP | claimed |
| US-20090286779-A1 | PYRAZOLOPYRIMIDINES AS LIPID KINASE INHIBITORS | NOVARTIS AG | 2009-11-19 | — | — | US | claimed |
| EP-2081933-B1 | PYRAZOLOPYRIMIDINES AS PI3K LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-03-23 | — | — | EP | disclosed |
| US-20090286779-A1 | PYRAZOLOPYRIMIDINES AS LIPID KINASE INHIBITORS | NOVARTIS AG | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286779-A1 | PYRAZOLOPYRIMIDINES AS LIPID KINASE INHIBITORS | ATR, ATM, CHEK1 | PIK3CG 12/4885MAPT 725/4885SMN1; SMN2 2315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.