Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237791 | 0.91 | PDE10A (0.66) | PDE10AALDH1A1KDM4EHPGDCYP1A2 | |
| SCHEMBL14237496 | 0.90 | PDE10A (0.53) | PDE10AALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL2499352 | 0.87 | PDE10A (0.54) | PDE10AALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL14237727 | 0.86 | PDE10A (0.56) | PDE10AALDH1A1KDM4EHPGDCYP1A2 | |
| SCHEMBL2497192 | 0.83 | PDE10A (0.58) | PDE10AALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL14237740 | 0.80 | PDE10A (0.61) | PDE10AALDH1A1KDM4EHPGDCYP1A2 | |
| SCHEMBL14237790 | 0.80 | PDE10A (0.68) | PDE10AALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL518472 | 0.79 | PDE10A (0.75) | PDE10AALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL2501874 | 0.79 | PDE10A (0.71) | PDE10AALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL2749730 | 0.78 | PDE10A (0.68) | PDE10AALDH1A1KDM4EHPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373641-B1 | PYRIDAZINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-12-19 | — | — | EP | claimed |