Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 7/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3740914 | 0.89 | HCRTR1 (0.43) | HCRTR1HCRTR2 | |
| SCHEMBL3732574 | 0.89 | HCRTR1 (0.43) | HCRTR1HCRTR2 | |
| SCHEMBL3732570 | 0.89 | HCRTR1 (0.43) | HCRTR1HCRTR2 | |
| SCHEMBL8161252 | 0.88 | HCRTR1 (0.39) | HCRTR1HCRTR2KCNH2HAT1EP300 | |
| SCHEMBL14238594 | 0.88 | HCRTR1 (0.36) | HCRTR1HCRTR2MEN1KMT2ANPC1 | |
| SCHEMBL8173702 | 0.84 | HAT1 (0.39) | HCRTR1HCRTR2MEN1KMT2ANPC1 | |
| SCHEMBL14238575 | 0.83 | HCRTR1 (0.35) | HCRTR1HCRTR2MEN1KMT2ANPC1 | |
| SCHEMBL8170431 | 0.82 | MEN1 (0.47) | MEN1KMT2ANPC1CYP2D6CYP2C19 | |
| SCHEMBL8174089 | 0.82 | MEN1 (0.41) | HCRTR1HCRTR2MEN1KMT2ANPC1 | |
| SCHEMBL8173895 | 0.82 | MEN1 (0.47) | MEN1KMT2ANPC1CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-B1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2012-12-12 | — | — | EP | disclosed |