Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 15/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | LDHB | P07195 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | FES | P07332 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | FER | P16591 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3461282 | 0.84 | ATR (0.48) | ATRLDHALDHBPRKDC | |
| SCHEMBL3459836 | 0.81 | ATR (0.49) | ATRLDHALDHBPRKDC | |
| SCHEMBL3461409 | 0.81 | ATR (0.56) | ATRLDHALDHBJAK2MAP4K4 | |
| SCHEMBL3461766 | 0.80 | ATR (0.51) | ATRLDHALDHBJAK2MAP4K4 | |
| SCHEMBL3461585 | 0.79 | ATR (0.56) | ATRLDHALDHBJAK2MAP4K4 | |
| SCHEMBL3460769 | 0.79 | ATR (0.53) | ATRLDHALDHBJAK2MAP4K4 | |
| SCHEMBL3461683 | 0.78 | ATR (0.54) | ATRLDHALDHBJAK2MAP4K4 | |
| SCHEMBL3460800 | 0.77 | ATR (0.57) | ATRLDHALDHBJAK2MAP4K4 | |
| SCHEMBL3461305 | 0.77 | ATR (0.58) | ATRLDHALDHBJAK2MAP4K4 | |
| SCHEMBL3460940 | 0.77 | ATR (0.53) | ATRLDHALDHBJAK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-B1 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2012-12-19 | — | — | EP | disclosed |