Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 17/20 | 0.77 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.77 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.77 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14325183 | 1.00 | MAP2K1 (0.77) | MAP2K1MAP2K2MAP2K5EIF2AK1CYP2C9 | |
| Azd-8330 SCHEMBL29360392 | 0.87 | MAP2K1 (1.00) | MAP2K1MAP2K2MAP2K5EIF2AK1CYP2C9 | |
| Azd-8330 SCHEMBL388533 | 0.87 | MAP2K1 (1.00) | MAP2K1MAP2K2MAP2K5EIF2AK1CYP2C9 | |
| SCHEMBL2341603 | 0.86 | MAP2K1 (0.80) | MAP2K1MAP2K2MAP2K5EIF2AK1CYP2C9 | |
| SCHEMBL391096 | 0.86 | MAP2K1 (0.77) | MAP2K1MAP2K2MAP2K5EIF2AK1KCNH2 | |
| SCHEMBL391097 | 0.86 | MAP2K1 (0.77) | MAP2K1MAP2K2MAP2K5EIF2AK1KCNH2 | |
| SCHEMBL391636 | 0.85 | MAP2K1 (0.82) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL392291 | 0.82 | MAP2K1 (0.77) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL391764 | 0.80 | MAP2K1 (0.85) | MAP2K1MAP2K2MAP2K5EIF2AK1CYP2C9 | |
| SCHEMBL19443280 | 0.80 | MAP2K1 (0.65) | MAP2K1MAP2K2MAP2K5EIF2AK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012171020-A1 | PROTEIN-POLYMER-DRUG CONJUGATES | MERSANA THERAPEUTICS, INC. (US) | 2012-12-13 | — | — | WO | disclosed |