Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2147629 | 1.00 | KDM4E (0.32) | KDM4EHSD17B10ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL31379 | 0.93 | — | — | |
| SCHEMBL2148341 | 0.90 | CHEK1 (0.32) | KDM4EHSD17B10ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL2148336 | 0.90 | CHEK1 (0.32) | KDM4EHSD17B10ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL2147497 | 0.89 | CHRM2 (0.34) | KDM4EALDH1A1 | |
| SCHEMBL12461044 | 0.89 | CHRM2 (0.34) | KDM4EALDH1A1 | |
| SCHEMBL2147530 | 0.89 | CHRM2 (0.34) | KDM4EALDH1A1 | |
| SCHEMBL12460799 | 0.89 | CHRM2 (0.34) | KDM4EALDH1A1 | |
| SCHEMBL15807506 | 0.89 | CHRM2 (0.34) | KDM4EALDH1A1 | |
| SCHEMBL584379 | 0.87 | KDM4E (0.34) | KDM4EHSD17B10ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9227971-B2 | Pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-01-05 | — | — | US | disclosed |
| US-20120322791-A1 | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322791-A1 | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS | MTOR, RICTOR, RPS6KA5 | KDM4E 620/4885HSD17B10 4456/4885ALDH1A1 2634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.