Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 13/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 12/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1424687 | 1.00 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1GRM4SMN1; SMN2POLB | |
| SCHEMBL1426289 | 0.76 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1POLBHTT | |
| SCHEMBL14134890 | 0.73 | GRM4 (0.47) | GRM4SMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL1426006 | 0.71 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL1424921 | 0.70 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1HTT | |
| SCHEMBL1425433 | 0.70 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1CNR1 | |
| SCHEMBL1425369 | 0.69 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1CNR1 | |
| SCHEMBL1425859 | 0.68 | HSP90AA1 (0.85) | HSP90AA1HSP90AB1 | |
| SCHEMBL1425467 | 0.68 | HSP90AA1 (0.71) | HSP90AA1HSP90AB1 | |
| SCHEMBL1425678 | 0.68 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118111-B1 | 2-AMIN0-5, 7-DIHYDR0-6H- PYRROLO [3, 4-D] PYRIMIDINE DERIVATIVES AS HSP-90 INHIBITORS FOR TREATING CANCER | PFIZER (US) | 2011-03-23 | — | — | EP | disclosed |
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | PFIZER INC. | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | HSP90AB2P, HSP90AB1, HSP90AA1 | HSP90AA1 3/4885HSP90AB1 2/4885GRM4 4742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.