Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.74 |
| ▸ | AHR | P35869 | 1/20 | 0.66 |
| ▸ | MAOB | P27338 | 1/20 | 0.64 |
| ▸ | F3 | P13726 | 1/20 | 0.58 |
| ▸ | BCHE | P06276 | 5/20 | 0.57 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.56 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 2/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1425221 | 1.00 | ABCG2 (0.74) | ABCG2AHRMAOBF3BCHE | |
| SCHEMBL1425782 | 0.95 | ABCG2 (0.74) | ABCG2AHRMAOBF3BCHE | |
| SCHEMBL1425780 | 0.95 | ABCG2 (0.74) | ABCG2AHRMAOBF3BCHE | |
| SCHEMBL1425801 | 0.89 | MAOB (0.80) | ABCG2AHRMAOBF3MAPT | |
| SCHEMBL1425803 | 0.89 | MAOB (0.80) | ABCG2AHRMAOBF3MAPT | |
| SCHEMBL8161647 | 0.87 | ABCG2 (0.65) | ABCG2AHRMAOBF3BCHE | |
| SCHEMBL8161646 | 0.87 | ABCG2 (0.65) | ABCG2AHRMAOBF3BCHE | |
| SCHEMBL1425139 | 0.86 | ABCG2 (0.73) | ABCG2MAPTKDM4ELMNA | |
| SCHEMBL1425144 | 0.86 | ABCG2 (0.73) | ABCG2MAPTKDM4ELMNA | |
| SCHEMBL996620 | 0.86 | ABCG2 (0.93) | ABCG2MAOBF3BCHECYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432669-B1 | 4-(C2-6 ALKOXY)-SUBSTITUTED CHALCONES AS THERAPEUTIC AGENTS | SPEAR THERAPEUTICS LTD (GB) | 2011-03-23 | — | — | EP | disclosed |
| EP-1432669-B1 | 4-(C2-6 ALKOXY)-SUBSTITUTED CHALCONES AS THERAPEUTIC AGENTS | SPEAR THERAPEUTICS LTD (GB) | 2011-03-23 | — | — | EP | disclosed |
| US-7112698-B2 | 4-(c2-6alkoxy)-substituted chalcones as therapeutic agents | SPEAR THERAPEUTICS LIMITED (GB) | 2006-09-26 | — | — | US | disclosed |
| US-20040259957-A1 | 4-(c2-6alkoxy)-substituted chalcones as therapeutic agents | SPEAR THERAPEUTICS LIMITED (GB) | 2004-12-23 | — | — | US | disclosed |
| EP-1432669-A1 | 4-(C2-6 ALKOXY)-SUBSTITUTED CHALCONES AS THERAPEUTIC AGENTS | Cancer Research Technology Limited (GB) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003029176-A1 | 4-(C2-6ALKOXY)-SUBSTITUTED CHALCONES AS THERAPEUTIC AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259957-A1 | 4-(c2-6alkoxy)-substituted chalcones as therapeutic agents | OXER1, ALK, BCL6 | ABCG2 191/4885AHR 162/4885MAOB 653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.