Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 17/20 | 0.63 |
| ▸ | ICOSLG | O75144 | 3/20 | 0.52 |
| ▸ | ICOS | Q9Y6W8 | 3/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | PRKCG | P05129 | 1/20 | 0.51 |
| ▸ | PRKCB | P05771 | 1/20 | 0.51 |
| ▸ | PRKCA | P17252 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | PRKCH | P24723 | 1/20 | 0.51 |
| ▸ | PRKCI | P41743 | 1/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.51 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.51 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.51 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2768695 | 0.79 | CHUK (0.67) | CHUKICOSLGICOSDYRK1AKDM4E | |
| SCHEMBL4818361 | 0.79 | CHUK (0.53) | CHUKICOSLGICOSPRKD3PRKCG | |
| SCHEMBL28644669 | 0.78 | MAPT (0.53) | KDM4EGABRPGABRDALDH1A1GABRA1 | |
| SCHEMBL14253008 | 0.77 | CHUK (1.00) | CHUKICOSLGICOSDYRK1AIKBKB | |
| SCHEMBL14253068 | 0.75 | CHUK (0.76) | CHUKICOSLGICOSDYRK1AIKBKB | |
| SCHEMBL14253048 | 0.73 | CHUK (0.59) | CHUKICOSLGICOSPRKD3PRKCG | |
| SCHEMBL4813555 | 0.71 | CYP11B1 (0.58) | CHUKPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL4823698 | 0.71 | CHUK (0.56) | CHUKICOSLGICOSKDM4EGABRP | |
| SCHEMBL14253067 | 0.71 | CHUK (0.68) | CHUKICOSLGICOSDYRK1AIKBKB | |
| SCHEMBL14253050 | 0.70 | CHUK (0.78) | CHUKICOSLGICOSDYRK1AIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348336-B2 | Substituted β-carbolines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-03-25 | — | — | US | disclosed |
| US-7348336-B2 | Substituted β-carbolines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-03-25 | — | — | US | disclosed |