Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 7/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.60 |
| ▸ | SYK | P43405 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.52 |
| ▸ | PRKCA | P17252 | 3/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | BCR | P11274 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14253938 | 0.95 | PIK3CG (0.66) | PIK3CGPIK3CAPIK3CBSYKMEN1 | |
| SCHEMBL14253939 | 0.92 | PIK3CG (0.56) | PIK3CGPIK3CAPIK3CBSYKMEN1 | |
| SCHEMBL14254240 | 0.90 | PIK3CG (0.53) | PIK3CGPIK3CAPIK3CBMEN1KMT2A | |
| SCHEMBL14253940 | 0.88 | PIK3CG (0.56) | PIK3CGPIK3CAPIK3CBSYKMEN1 | |
| SCHEMBL14253937 | 0.87 | PIK3CA (0.57) | PIK3CGPIK3CAPIK3CBMEN1KMT2A | |
| SCHEMBL14254189 | 0.87 | JAK2 (0.55) | PIK3CGPIK3CAPIK3CBSYKMEN1 | |
| SCHEMBL14253968 | 0.87 | PIK3CG (0.57) | PIK3CGPIK3CAPIK3CBMEN1KMT2A | |
| SCHEMBL14253971 | 0.87 | ABL1 (0.56) | PIK3CGPIK3CAPIK3CBMEN1KMT2A | |
| SCHEMBL14254192 | 0.86 | PIK3CA (0.71) | PIK3CGPIK3CAPIK3CBMEN1KMT2A | |
| SCHEMBL14254219 | 0.85 | PIK3CG (0.56) | PIK3CGPIK3CAPIK3CBSYKMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348335-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-03-25 | — | — | US | disclosed |