Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 17/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 16/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1425709 | 0.93 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1CYP3A4HTR2AHTR2C | |
| SCHEMBL1425550 | 0.93 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL1426044 | 0.91 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1 | |
| SCHEMBL1425687 | 0.91 | GAA (0.44) | HSP90AA1HSP90AB1CYP3A4HTR2AHTR2C | |
| SCHEMBL14135118 | 0.90 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1PDE4APDE4BPDE4C | |
| SCHEMBL13394171 | 0.89 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL1425498 | 0.89 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL13394155 | 0.88 | HTR2A (0.42) | HSP90AA1HSP90AB1CYP3A4HTR2AHTR2C | |
| SCHEMBL1425798 | 0.87 | POLB (0.46) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL1425694 | 0.86 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118111-B1 | 2-AMIN0-5, 7-DIHYDR0-6H- PYRROLO [3, 4-D] PYRIMIDINE DERIVATIVES AS HSP-90 INHIBITORS FOR TREATING CANCER | PFIZER (US) | 2011-03-23 | — | — | EP | disclosed |
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | PFIZER INC. | 2010-04-15 | — | — | US | disclosed |
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | PFIZER INC. | 2010-04-15 | — | — | US | disclosed |
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | PFIZER INC. | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | HSP90AB2P, HSP90AB1, HSP90AA1 | HSP90AA1 3/4885HSP90AB1 2/4885PDE4A 3622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.