Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT8 | Q9H7Z6 | 5/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.56 |
| ▸ | MEN1 | O00255 | 8/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.56 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | NSD2 | O96028 | 1/20 | 0.51 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.51 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.51 |
| ▸ | GRK2 | P25098 | 1/20 | 0.51 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.51 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.51 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14255659 | 0.82 | KAT8 (0.52) | KAT8KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL245319 | 0.80 | KMT2A (0.66) | KAT8KMT2AMEN1MAPTNPSR1 | |
| SCHEMBL245318 | 0.80 | KMT2A (0.66) | KAT8KMT2AMEN1MAPTNPSR1 | |
| SCHEMBL22523764 | 0.79 | KMT2A (0.80) | KAT8KMT2AMEN1MAPTNPSR1 | |
| SCHEMBL420585 | 0.78 | KMT2A (0.72) | KAT8KMT2AMEN1MAPTNPSR1 | |
| SCHEMBL446468 | 0.76 | KAT8 (0.57) | KAT8KMT2AMEN1MAPTNPSR1 | |
| SCHEMBL420541 | 0.76 | KAT8 (0.57) | KAT8KMT2AMEN1MAPTNPSR1 | |
| SCHEMBL446664 | 0.76 | KMT2A (0.66) | KAT8KMT2AMEN1MAPTNPSR1 | |
| SCHEMBL420579 | 0.76 | KMT2A (0.66) | KAT8KMT2AMEN1MAPTNPSR1 | |
| SCHEMBL446663 | 0.76 | KMT2A (0.66) | KAT8KMT2AMEN1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900728-A1 | PHARMACEUTICAL COMPOSITION COMPRISING PYRAZOLONE DERIVATIVE | Genecare Research Institute Co., Ltd (JP) | 2008-03-19 | — | — | EP | disclosed |