Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 13/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 13/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1425765 | 0.92 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1DPP4MEN1KMT2A | |
| SCHEMBL26435800 | 0.88 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL1425517 | 0.85 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL12811872 | 0.85 | HSP90AB1 (0.43) | HSP90AA1HSP90AB1CDC7DBF4CNR1 | |
| SCHEMBL1425382 | 0.83 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL1425453 | 0.83 | HSP90AB1 (0.43) | HSP90AA1HSP90AB1MEN1KMT2ACNR1 | |
| SCHEMBL1425375 | 0.83 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL1426111 | 0.82 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL1425421 | 0.82 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL14135171 | 0.81 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118111-B1 | 2-AMIN0-5, 7-DIHYDR0-6H- PYRROLO [3, 4-D] PYRIMIDINE DERIVATIVES AS HSP-90 INHIBITORS FOR TREATING CANCER | PFIZER (US) | 2011-03-23 | — | — | EP | disclosed |
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | PFIZER INC. | 2010-04-15 | — | — | US | disclosed |
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | PFIZER INC. | 2010-04-15 | — | — | US | disclosed |
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | PFIZER INC. | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | HSP90AB2P, HSP90AB1, HSP90AA1 | HSP90AA1 3/4885HSP90AB1 2/4885DPP4 3302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.