Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 19/20 | 0.57 |
| ▸ | HSP90AB1 | P08238 | 18/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13394096 | 0.86 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1CYP3A4DPP4DPP7 | |
| Hydrochloric Acid SCHEMBL1425883 | 0.85 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1CYP3A4DPP4DPP7 | |
| SCHEMBL1426159 | 0.79 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL1425956 | 0.78 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL1426226 | 0.76 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL1425491 | 0.76 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL1426349 | 0.76 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL1425488 | 0.75 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL1425459 | 0.75 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL1425615 | 0.75 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118111-B1 | 2-AMIN0-5, 7-DIHYDR0-6H- PYRROLO [3, 4-D] PYRIMIDINE DERIVATIVES AS HSP-90 INHIBITORS FOR TREATING CANCER | PFIZER (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2118111-B1 | 2-AMIN0-5, 7-DIHYDR0-6H- PYRROLO [3, 4-D] PYRIMIDINE DERIVATIVES AS HSP-90 INHIBITORS FOR TREATING CANCER | PFIZER (US) | 2011-03-23 | — | — | EP | disclosed |
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | PFIZER INC. | 2010-04-15 | — | — | US | disclosed |
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | PFIZER INC. | 2010-04-15 | — | — | US | disclosed |
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | PFIZER INC. | 2010-04-15 | — | — | US | disclosed |
| WO-2008096218-A1 | 2-AMIN0-5, 7-DIHYDR0-6H- PYRROLO [3, 4-D] PYRIMIDINE DERIVATIVES AS HSP-90 INHIBITORS FOR TREATING CANCER | PFIZER INC. (US) | 2008-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | HSP90AB2P, HSP90AB1, HSP90AA1 | HSP90AA1 3/4885HSP90AB1 2/4885CYP3A4 2698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.