Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.75 |
| ▸ | CA12 | O43570 | 3/20 | 0.66 |
| ▸ | CA4 | P22748 | 3/20 | 0.66 |
| ▸ | CA7 | P43166 | 3/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | TYR | P14679 | 1/20 | 0.66 |
| ▸ | CA2 | P00918 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.62 |
| ▸ | APEX1 | P27695 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.58 |
| ▸ | P4HB | P07237 | 2/20 | 0.57 |
| ▸ | SYNJ2 | O15056 | 1/20 | 0.57 |
| ▸ | ALPL | P05186 | 1/20 | 0.56 |
| ▸ | ALPI | P09923 | 1/20 | 0.56 |
| ▸ | ALPG | P10696 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14259870 | 0.90 | AKR1B1 (0.67) | AKR1B1CA12CA4CA7CYP3A4 | |
| SCHEMBL31337090 | 0.88 | AKR1B1 (0.89) | AKR1B1CA12CA4CA7CYP3A4 | |
| SCHEMBL14613942 | 0.88 | AKR1B1 (0.77) | AKR1B1CA12CA4CA7CYP3A4 | |
| SCHEMBL27062116 | 0.88 | AKR1B1 (0.69) | AKR1B1CA12CA4CA7CYP3A4 | |
| SCHEMBL27062124 | 0.88 | AKR1B1 (0.69) | AKR1B1CA12CA4CA7CYP3A4 | |
| SCHEMBL18307145 | 0.88 | AKR1B1 (0.69) | AKR1B1CA12CA4CA7CYP3A4 | |
| SCHEMBL18307185 | 0.88 | AKR1B1 (0.69) | AKR1B1CA12CA4CA7CYP3A4 | |
| SCHEMBL30186765 | 0.86 | AKR1B1 (0.76) | AKR1B1CA12CA4CA7CYP3A4 | |
| SCHEMBL18307158 | 0.85 | AKR1B1 (0.65) | AKR1B1CA12CA4CA7CYP3A4 | |
| SCHEMBL18307172 | 0.85 | AKR1B1 (0.65) | AKR1B1CA12CA4CA7CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076738-A1 | Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds | GILEAD SCIENCES, INC. | 2008-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076738-A1 | Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds | TYMP, PNP, PIKFYVE | AKR1B1 3123/4885CA12 4829/4885CA4 4662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.