SCHEMBL1426296

SCHEMBL1426296

Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2

nearest known ligand 0.70

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 19/20 0.70
DDB1 Q16531 10/20 0.60
IKZF3 Q9UKT9 4/20 0.60
TNF P01375 3/20 0.60
IL1B P01584 3/20 0.60
IKZF1 Q13422 2/20 0.60
BRD4 O60885 1/20 0.60
TBXA2R P21731 1/20 0.53
ALDH1A1 P00352 1/20 0.46
CHRM2 P08172 1/20 0.46
OPRM1 P35372 1/20 0.46
CYP1A2 P05177 1/20 0.46
TSHR P16473 1/20 0.46
TDP1 Q9NUW8 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23065966 0.84 CRBN (0.70) CRBNDDB1IKZF3TNFIL1B
SCHEMBL19248974 0.84 CRBN (0.70) CRBNDDB1IKZF3TNFIL1B
SCHEMBL29878132 0.84 CRBN (0.70) CRBNDDB1IKZF3TNFIL1B
SCHEMBL21602693 0.84 CRBN (0.70) CRBNDDB1IKZF3TNFIL1B
SCHEMBL25423114 0.84 CRBN (0.65) CRBNDDB1IKZF3TNFIL1B
SCHEMBL1499656 0.83 CRBN (1.00) CRBNDDB1IKZF3TNFIL1B
SCHEMBL6180704 0.83 CRBN (1.00) CRBNDDB1IKZF3TNFIL1B
SCHEMBL6178113 0.83 CRBN (1.00) CRBNDDB1IKZF3TNFIL1B
SCHEMBL29943635 0.83 CRBN (1.00) CRBNDDB1IKZF3TNFIL1B
SCHEMBL19278144 0.82 CRBN (0.67) CRBNDDB1IKZF3TNFIL1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015110659-A1 METHODS OF IMMUNIZATION WITH A VACCINE INDUCING A HUMORAL IMMUNE RESPONSE AND WITH A VACCINE INDUCING A CELLULAR IMMUNE RESPONSE BIONOR IMMUNO AS (NO) 2015-07-30 WO claimed
EP-2301535-A1 Immunological uses of immunomodulatory compounds for vaccine and anti-infectious disease therapy CELGENE CORPORATION (US) 2011-03-30 EP claimed
US-20210163442-A1 CRYSTALLINE FORMS OF LENALIDOMIDE BIOCON LIMITED (IN) 2021-06-03 US disclosed
EP-3524253-A1 TUMOR SUPPRESSION USING HUMAN PLACENTAL PERFUSATE AND HUMAN PLACENTA-DERIVED INTERMEDIATE NATURAL KILLER CELLS Celularity, Inc. (US) 2019-08-14 EP disclosed
US-10001483-B2 Methods for the treatment of Kaposi's sarcoma or KSHV-induced lymphoma using immunomodulatory compounds, and uses of biomarkers CELGENE CORPORATION (US) 2018-06-19 US disclosed
EP-3182996-A1 METHODS OF TREATING MULTIPLE MYELOMA WITH IMMUNOMODULATORY COMPOUNDS IN COMBINATION WITH ANTIBODIES Celgene Corporation (US) 2017-06-28 EP disclosed
US-20170157103-A1 METHODS OF TREATING DIFFUSE LARGE B-CELL LYMPHOMA USING 3-(4-AMINO-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE CELGENE CORPORATION 2017-06-08 US disclosed
CN-103393681-B Methodand composition for treatment and management of multiple myeloma 细胞基因公司 2017-04-12 CN disclosed
WO-2016029004-A1 METHODS OF TREATING MULTIPLE MYELOMA WITH IMMUNOMODULATORY COMPOUNDS IN COMBINATION WITH ANTIBODIES CELGENE CORPORATION (US) 2016-02-25 WO disclosed
EP-2981262-A1 METHODS AND COMPOSITIONS USING 4-AMINO-2-(2,6-DIOXO-PIPERIDINE-3-YL)-ISOINDOLINE-1,3-DIONE FOR TREATMENT AND MANAGEMENT OF CENTRAL NERVOUS SYSTEM CANCERS Celgene Corporation (US) 2016-02-10 EP disclosed
CN-105246480-A Methods and compositions for treating and controlling central nervous system cancer using 4-amino-2- (2, 6-dioxo-piperidin-3-yl) -isoindoline-1, 3-dione CELGENE CORP 2016-01-13 CN disclosed
WO-2014165482-A1 METHODS AND COMPOSITIONS USING 4-AMINO-2-(2,6-DIOXO-PIPERIDINE-3-YL)-ISOINDOLINE-1,3-DIONE FOR TREATMENT AND MANAGEMENT OF CENTRAL NERVOUS SYSTEM CANCERS CELGENE CORPORATION (US) 2014-10-09 WO disclosed
CN-103097520-A Method for producing natural killer cells ANTHROGENESIS CORP 2013-05-08 CN disclosed
EP-2504703-A1 IMMUNOMODULATORY COMPOUNDS FOR THE RESTORATION OF VITAMIN D SENSITIVITY IN VITAMIN D RESISTANT TUMOR CELLS Celgene Corporation (US) 2012-10-03 EP disclosed
WO-2012078492-A1 A COMBINATION THERAPY WITH LENALIDOMIDE AND A CDK INHIBITOR FOR TREATING MULTIPLE MYELOMA CELGENE CORPORATION (US) 2012-06-14 WO disclosed
WO-2011066351-A1 IMMUNOMODULATORY COMPOUNDS FOR THE RESTORATION OF VITAMIN D SENSITIVITY IN VITAMIN D RESISTANT TUMOR CELLS CELGENE CORPORATION (US) 2011-06-03 WO disclosed
WO-2011066351-A1 IMMUNOMODULATORY COMPOUNDS FOR THE RESTORATION OF VITAMIN D SENSITIVITY IN VITAMIN D RESISTANT TUMOR CELLS CELGENE CORPORATION (US) 2011-06-03 WO disclosed
EP-1933818-B1 METHODS AND COMPOSITIONS USING IMMUNOMODULATORY COMPOUNDS FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH LOW PLASMA LEPTIN LEVELS CELGENE CORP (US) 2011-01-19 EP disclosed
WO-2009105256-A2 METHOD OF TREATING CANCER BY ADMINISTERING AN IMMUNOMODULATORY COMPOUND IN COMBINATION WITH A CD40 ANTIBODY OR CD40 LIGAND CELGENE CORPORATION (US) 2009-08-27 WO disclosed
WO-2009061445-A2 USE OF IMMUNOMODULATORY COMPOUNDS FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION CELGENE CORPORATION (US) 2009-05-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10001483-B2 Methods for the treatment of Kaposi's sarcoma or KSHV-induced lymphoma using immunomodulatory compounds, and uses of biomarkers BCL6, MALT1, BCL3 CRBN 1487/4885DDB1 100/4885IKZF3 46/4885
US-20210163442-A1 CRYSTALLINE FORMS OF LENALIDOMIDE CRBN, SALL4, RDX CRBN 1/4885DDB1 235/4885IKZF3 1856/4885
US-20170157103-A1 METHODS OF TREATING DIFFUSE LARGE B-CELL LYMPHOMA USING 3-(4-AMINO-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE BCL6, BCL3, MALT1 CRBN 745/4885DDB1 96/4885IKZF3 975/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.