Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.50 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.50 |
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | GHSR | Q92847 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | RARB | P10826 | 1/20 | 0.48 |
| ▸ | F13A1 | P00488 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14263146 | 0.90 | S1PR1 (0.61) | S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL14263209 | 0.89 | NPC1 (0.52) | NPC1RAB9AHPGDSMN1; SMN2POLB | |
| SCHEMBL14263230 | 0.86 | S1PR4 (0.46) | NPC1RAB9AHPGDSMN1; SMN2POLB | |
| SCHEMBL14263145 | 0.83 | S1PR1 (0.64) | S1PR4S1PR1S1PR3S1PR5CA12 | |
| SCHEMBL14263175 | 0.82 | S1PR1 (0.73) | S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL4983989 | 0.81 | S1PR1 (0.75) | S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL4629063 | 0.81 | S1PR1 (0.75) | S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL4981018 | 0.81 | S1PR1 (0.75) | S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL4981029 | 0.81 | S1PR1 (0.75) | S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL14263246 | 0.80 | S1PR1 (0.58) | NPC1RAB9ASMN1; SMN2S1PR4S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080064662-A1 | Methods and compositions for modulating sphingosine -1- phosphate (S1P) receptor activity | PRAECIS PHARMACEUTICALS INCORPORATED (US) | 2008-03-13 | — | — | US | disclosed |
| US-20080064662-A1 | Methods and compositions for modulating sphingosine -1- phosphate (S1P) receptor activity | PRAECIS PHARMACEUTICALS INCORPORATED (US) | 2008-03-13 | — | — | US | disclosed |
| US-7241812-B2 | Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity | PRAECIS PHARMACEUTICALS, INC. (US) | 2007-07-10 | — | — | US | disclosed |
| US-7241812-B2 | Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity | PRAECIS PHARMACEUTICALS, INC. (US) | 2007-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064662-A1 | Methods and compositions for modulating sphingosine -1- phosphate (S1P) receptor activity | S1PR1, S1PR2, S1PR3 | NPC1 246/4885RAB9A 2800/4885HPGD 2554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.