Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KIT | P10721 | 3/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14263335 | 0.94 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL14263311 | 0.92 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL4980488 | 0.92 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL14263312 | 0.91 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL14263304 | 0.87 | KDR (0.44) | NPC1RAB9ASMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL14263298 | 0.86 | KDR (0.43) | NPC1RAB9ASMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL4980267 | 0.83 | KDR (0.43) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL14263328 | 0.83 | TP53 (0.54) | NPC1RAB9ASMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL4980958 | 0.82 | MAPK1 (0.53) | SMN1; SMN2MAPK1NPSR1TRPC5GAA | |
| SCHEMBL14263329 | 0.82 | HDAC6 (0.50) | NPC1RAB9ASMN1; SMN2KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7338959-B2 | Diamino-pyrimidines and their use as angiogenesis inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338959-B2 | Diamino-pyrimidines and their use as angiogenesis inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2008-03-04 | — | — | US | disclosed |
| EP-1487824-B1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-06-20 | — | — | EP | disclosed |