Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.60 |
| ▸ | BIRC2 | Q13490 | 5/20 | 0.34 |
| ▸ | XIAP | P98170 | 2/20 | 0.34 |
| ▸ | BIRC3 | Q13489 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | STAT6 | P42226 | 6/20 | 0.33 |
| ▸ | CASP9 | P55211 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.31 |
| ▸ | STAT5A | P42229 | 1/20 | 0.31 |
| ▸ | STAT5B | P51692 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58688 | 0.91 | TUBB1 (0.59) | TUBB1BIRC2XIAPBIRC3STAT6 | |
| SCHEMBL4368595 | 0.91 | TUBB1 (0.59) | TUBB1BIRC2XIAPBIRC3STAT6 | |
| SCHEMBL13850283 | 0.91 | TUBB1 (0.61) | TUBB1BIRC2XIAPBIRC3STAT6 | |
| SCHEMBL14185880 | 0.90 | TUBB1 (0.58) | TUBB1BIRC2XIAPBIRC3STAT6 | |
| SCHEMBL57417 | 0.90 | TUBB1 (0.58) | TUBB1BIRC2XIAPBIRC3STAT6 | |
| SCHEMBL88381 | 0.90 | TUBB1 (0.58) | TUBB1BIRC2XIAPBIRC3STAT6 | |
| SCHEMBL57912 | 0.89 | TUBB1 (0.61) | TUBB1BIRC2XIAPBIRC3STAT6 | |
| SCHEMBL58756 | 0.89 | TUBB1 (0.61) | TUBB1BIRC2XIAPBIRC3STAT6 | |
| SCHEMBL57941 | 0.89 | TUBB1 (0.61) | TUBB1BIRC2XIAPBIRC3STAT6 | |
| SCHEMBL4366593 | 0.89 | TUBB1 (0.61) | TUBB1BIRC2XIAPBIRC3STAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051434-A1 | synthetic analog of Hemiasterlin; anticarcinogenic agent; restenosis of blood vessels subject to traumas such as angioplasty and stenting; safe and effective, while retaining stability in biological media; exhibit low cytotoxicity to non-dividing normal cells | EISAI CO., LTD. (JP) | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051434-A1 | synthetic analog of Hemiasterlin; anticarcinogenic agent; restenosis of blood vessels subject to traumas such as angioplasty and stenting; safe and effective, while retaining stability in biological media; exhibit low cytotoxicity to non-dividing normal cells | DHCR7, CYP46A1, NR1H2 | TUBB1 1157/4885BIRC2 1401/4885XIAP 448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.