Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.53 |
| ▸ | AXL | P30530 | 7/20 | 0.51 |
| ▸ | FLT3 | P36888 | 5/20 | 0.47 |
| ▸ | KIT | P10721 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14275800 | 0.98 | AXL (0.53) | BACE1AXLFLT3KITJAK2 | |
| SCHEMBL14275790 | 0.98 | AXL (0.53) | BACE1AXLFLT3KITJAK2 | |
| SCHEMBL14275798 | 0.98 | BACE1 (0.51) | BACE1AXLFLT3KITJAK2 | |
| SCHEMBL14275804 | 0.95 | BACE1 (0.49) | BACE1AXLFLT3KITJAK2 | |
| SCHEMBL14275794 | 0.95 | BACE1 (0.49) | BACE1AXLFLT3KITJAK2 | |
| SCHEMBL14275789 | 0.94 | AXL (0.56) | BACE1AXLFLT3KITJAK2 | |
| SCHEMBL14275806 | 0.94 | BACE1 (0.49) | BACE1AXLFLT3KITJAK2 | |
| SCHEMBL14275780 | 0.93 | BACE1 (0.47) | BACE1AXLFLT3KITJAK2 | |
| SCHEMBL14275805 | 0.93 | BACE1 (0.48) | BACE1AXLFLT3KITJAK2 | |
| SCHEMBL14275788 | 0.92 | AXL (0.54) | BACE1AXLFLT3KITJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329652-B2 | Diaminotriazole compounds useful as protein kinase inhibitors | VERTEX PHARAMACEUTICALS INCORPORATED (US) | 2008-02-12 | — | — | US | disclosed |
| US-7329652-B2 | Diaminotriazole compounds useful as protein kinase inhibitors | VERTEX PHARAMACEUTICALS INCORPORATED (US) | 2008-02-12 | — | — | US | disclosed |