SCHEMBL14276196

SCHEMBL14276196

FC(F)(F)c1ccc(-c2cc(Oc3cccc4sc(-c5cccc(C(F)(F)F)c5)nc34)ncn2)cc1

nearest known ligand 0.74

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 2/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1043368 0.90 TRPV1 (0.65) TRPV1
SCHEMBL14276193 0.89 TRPV1 (0.61) TRPV1
SCHEMBL14276195 0.87 TRPV1 (0.61) TRPV1
SCHEMBL1041789 0.86 TRPV1 (0.72) TRPV1
SCHEMBL1038985 0.85 TRPV1 (0.68) TRPV1
SCHEMBL9927479 0.85 TRPV1 (0.70) TRPV1
SCHEMBL1042239 0.85 TRPV1 (0.68) TRPV1
SCHEMBL1041881 0.85 TRPV1 (0.68) TRPV1
Trifluoroacetic Acid SCHEMBL1075299 0.85 TRPV1 (0.65) TRPV1
SCHEMBL1042735 0.82 TRPV1 (0.78) TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7332511-B2 Vanilloid receptor ligands and their use in treatments AMGEN INC. (US) 2008-02-19 US disclosed
US-7332511-B2 Vanilloid receptor ligands and their use in treatments AMGEN INC. (US) 2008-02-19 US disclosed