Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 14/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.44 |
| ▸ | SRC | P12931 | 10/20 | 0.44 |
| ▸ | SYK | P43405 | 10/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5682646 | 0.90 | GSK3A (0.46) | GSK3AMAPK14SRCSYKCYP3A4 | |
| SCHEMBL14276170 | 0.89 | MAPK14 (0.49) | GSK3AMAPK14SRCSYKCYP3A4 | |
| SCHEMBL14276146 | 0.89 | GSK3A (0.48) | GSK3AMAPK14SRCSYKCYP3A4 | |
| SCHEMBL14276144 | 0.89 | MAPK14 (0.51) | GSK3AMAPK14SRCSYKCYP3A4 | |
| SCHEMBL5682531 | 0.87 | MAPK14 (0.55) | GSK3AMAPK14SRCSYKCYP3A4 | |
| SCHEMBL14276179 | 0.85 | MAPK14 (0.50) | GSK3AMAPK14SRCSYKCYP3A4 | |
| SCHEMBL14276256 | 0.85 | MAPK14 (0.49) | GSK3AMAPK14SRCSYKCYP3A4 | |
| SCHEMBL14276141 | 0.84 | MAPK14 (0.50) | GSK3AMAPK14SRCSYKCYP3A4 | |
| SCHEMBL5682445 | 0.83 | GSK3A (0.50) | GSK3AMAPK14SRCSYKCYP3A4 | |
| SCHEMBL5685356 | 0.83 | MAPK14 (0.49) | GSK3AMAPK14SRCSYKCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |