SCHEMBL14276293

SCHEMBL14276293

FC(F)(F)c1ccc(-c2cc(Oc3cccnc3Cl)ncn2)cc1

nearest known ligand 0.71

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 3/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1042476 0.85 TRPV1 (0.60) TRPV1
SCHEMBL1042871 0.83 TRPV1 (0.64) TRPV1
SCHEMBL1040298 0.82 TRPV1 (0.63) TRPV1
SCHEMBL1041153 0.80 TRPV1 (0.60) TRPV1
SCHEMBL1040833 0.80 TRPV1 (0.54) TRPV1
SCHEMBL1039116 0.79 TRPV1 (0.58) TRPV1
SCHEMBL1041450 0.78 TRPV1 (0.58) TRPV1
SCHEMBL1041548 0.78 TRPV1 (0.60) TRPV1
SCHEMBL14276277 0.78 TRPV1 (0.58) TRPV1
SCHEMBL1043128 0.77 TRPV1 (0.51) TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7332511-B2 Vanilloid receptor ligands and their use in treatments AMGEN INC. (US) 2008-02-19 US disclosed
US-7332511-B2 Vanilloid receptor ligands and their use in treatments AMGEN INC. (US) 2008-02-19 US disclosed