Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 3/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 5/20 | 0.37 |
| ▸ | ARG1 | P05089 | 2/20 | 0.34 |
| ▸ | ARG2 | P78540 | 2/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14278710 | 1.00 | S1PR1 (0.45) | S1PR1S1PR3S1PR5S1PR4OPRD1 | |
| SCHEMBL3429892 | 1.00 | S1PR1 (0.45) | S1PR1S1PR3S1PR5S1PR4OPRD1 | |
| SCHEMBL14278763 | 0.91 | S1PR1 (0.40) | S1PR1S1PR3S1PR5S1PR4LTA4H | |
| SCHEMBL14278741 | 0.91 | S1PR1 (0.40) | S1PR1S1PR3S1PR5S1PR4LTA4H | |
| SCHEMBL3429891 | 0.88 | S1PR1 (0.45) | S1PR1S1PR3S1PR5S1PR4LTA4H | |
| SCHEMBL13400446 | 0.87 | S1PR1 (0.57) | S1PR1S1PR3S1PR5S1PR4OPRD1 | |
| SCHEMBL13400436 | 0.87 | S1PR1 (0.57) | S1PR1S1PR3S1PR5S1PR4OPRD1 | |
| SCHEMBL3424443 | 0.86 | S1PR1 (0.41) | S1PR1S1PR3S1PR5S1PR4LTA4H | |
| SCHEMBL3429794 | 0.84 | S1PR1 (0.40) | S1PR1S1PR3S1PR5S1PR4LTA4H | |
| SCHEMBL14278779 | 0.84 | S1PR1 (0.42) | S1PR1S1PR3S1PR5S1PR4LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613619-B1 | QUINAZOLINE DERIVATIVES FOR TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-03-26 | — | — | EP | disclosed |