Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 3/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18743820 | 0.93 | KDM1A (0.47) | KDM1ADPP4METAP1DPP7MEN1 | |
| SCHEMBL13793412 | 0.79 | EPHX2 (0.43) | KDM1AEPHX2DPP4METAP1DPP7 | |
| SCHEMBL12258085 | 0.79 | KDM1A (0.39) | KDM1ADPP4METAP1DPP7MEN1 | |
| SCHEMBL26292943 | 0.75 | EPHX2 (0.46) | EPHX2DPP4METAP1DPP7MEN1 | |
| SCHEMBL7519699 | 0.74 | CA12 (0.51) | EPHX2DPP7MEN1KMT2AKDM4E | |
| SCHEMBL7077493 | 0.72 | EPHX2 (0.48) | EPHX2DPP4METAP1DPP7MEN1 | |
| SCHEMBL7764226 | 0.72 | EPHX2 (0.48) | EPHX2DPP4METAP1DPP7MEN1 | |
| SCHEMBL23222183 | 0.72 | EPHX2 (0.42) | EPHX2KMT2AHTTEPHX1 | |
| SCHEMBL12521938 | 0.72 | EPHX2 (0.65) | EPHX2KDM4EEPHX1 | |
| SCHEMBL23165798 | 0.72 | EPHX2 (0.43) | EPHX2DPP4METAP1DPP7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320986-B2 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBOTT LABORTORIES (US) | 2008-01-22 | — | — | US | disclosed |
| US-7320986-B2 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBOTT LABORTORIES (US) | 2008-01-22 | — | — | US | disclosed |