Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 18/20 | 0.71 |
| ▸ | IKBKB | O14920 | 17/20 | 0.71 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | AURKAIP1 | Q9NWT8 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13505067 | 0.85 | IKBKB (0.85) | CHUKIKBKBROCK1CYP2C9NEK1 | |
| SCHEMBL3417659 | 0.83 | IKBKB (1.00) | CHUKIKBKBROCK1CYP2C9NEK1 | |
| SCHEMBL3412863 | 0.82 | IKBKB (0.89) | CHUKIKBKBROCK1CYP2C9NEK1 | |
| SCHEMBL3609319 | 0.80 | IKBKB (0.73) | CHUKIKBKBROCK1CYP2C9NEK1 | |
| SCHEMBL13505136 | 0.80 | CHUK (0.67) | CHUKIKBKBROCK1CYP2C9NEK1 | |
| SCHEMBL13505129 | 0.79 | IKBKB (0.71) | CHUKIKBKBROCK1CYP2C9NEK1 | |
| SCHEMBL3413368 | 0.79 | IKBKB (0.80) | CHUKIKBKBROCK1CYP2C9NEK1 | |
| SCHEMBL4456139 | 0.78 | IKBKB (0.69) | CHUKIKBKBROCK1CYP2C9NEK1 | |
| SCHEMBL13013002 | 0.78 | CHUK (0.69) | CHUKIKBKBROCK1CYP2C9NEK1 | |
| SCHEMBL3616050 | 0.78 | IKBKB (0.69) | CHUKIKBKBROCK1CYP2C9NEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008034860-A1 | PYRROLO[2, 3-B]PYRIDIN-4-YL-BENZENESULFONAMIDE COMPOUNDS AS IKK2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-03-27 | — | — | WO | disclosed |