Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.66 |
| ▸ | JAK1 | P23458 | 8/20 | 0.66 |
| ▸ | TYK2 | P29597 | 6/20 | 0.65 |
| ▸ | JAK3 | P52333 | 5/20 | 0.62 |
| ▸ | RPS6KA2 | Q15349 | 12/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2569417 | 0.86 | JAK2 (0.61) | JAK2JAK1TYK2JAK3RPS6KA2 | |
| SCHEMBL3614167 | 0.83 | JAK2 (0.58) | JAK2JAK1TYK2JAK3RPS6KA2 | |
| SCHEMBL2569413 | 0.79 | JAK2 (0.73) | JAK2JAK1TYK2JAK3RPS6KA2 | |
| SCHEMBL2573634 | 0.79 | JAK2 (1.00) | JAK2JAK1TYK2JAK3RPS6KA2 | |
| SCHEMBL2573422 | 0.79 | JAK2 (1.00) | JAK2JAK1TYK2JAK3RPS6KA2 | |
| SCHEMBL2571709 | 0.79 | JAK2 (0.65) | JAK2JAK1TYK2JAK3RPS6KA2 | |
| SCHEMBL2572342 | 0.78 | JAK2 (0.82) | JAK2JAK1TYK2JAK3RPS6KA2 | |
| SCHEMBL2571101 | 0.78 | JAK2 (0.82) | JAK2JAK1TYK2JAK3RPS6KA2 | |
| SCHEMBL2569558 | 0.78 | JAK2 (0.64) | JAK2JAK1TYK2JAK3RPS6KA2 | |
| SCHEMBL2574543 | 0.77 | JAK2 (0.79) | JAK2JAK1TYK2JAK3RPS6KA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008031594-A1 | BENZOXAZOLES AND OXAZOLOPYRIDINES BEING USEFUL AS JANUS KINASES INHIBITORS | NOVARTIS AG (CH) | 2008-03-20 | — | — | WO | disclosed |