Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 14/20 | 0.73 |
| ▸ | JAK2 | O60674 | 13/20 | 0.73 |
| ▸ | TYK2 | P29597 | 13/20 | 0.73 |
| ▸ | JAK3 | P52333 | 12/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RPS6KA2 | Q15349 | 4/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2574189 | 0.90 | JAK1 (0.73) | JAK1JAK2TYK2JAK3RPS6KA2 | |
| SCHEMBL12172204 | 0.87 | JAK1 (0.66) | JAK1JAK2TYK2JAK3RPS6KA2 | |
| SCHEMBL2575965 | 0.84 | JAK1 (1.00) | JAK1JAK2TYK2JAK3RPS6KA2 | |
| SCHEMBL2572213 | 0.83 | JAK1 (0.92) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL12172234 | 0.82 | JAK1 (0.84) | JAK1JAK2TYK2JAK3RPS6KA2 | |
| SCHEMBL2575451 | 0.82 | JAK1 (0.84) | JAK1JAK2TYK2JAK3RPS6KA2 | |
| SCHEMBL2575781 | 0.82 | JAK1 (0.86) | JAK1JAK2TYK2JAK3RPS6KA2 | |
| SCHEMBL2574413 | 0.81 | JAK1 (1.00) | JAK1JAK2TYK2JAK3RPS6KA2 | |
| SCHEMBL2571627 | 0.81 | JAK1 (0.73) | JAK1JAK2TYK2JAK3RPS6KA2 | |
| SCHEMBL2571758 | 0.81 | JAK1 (0.82) | JAK1JAK2TYK2JAK3RPS6KA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008031594-A1 | BENZOXAZOLES AND OXAZOLOPYRIDINES BEING USEFUL AS JANUS KINASES INHIBITORS | NOVARTIS AG (CH) | 2008-03-20 | — | — | WO | disclosed |