Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 14/20 | 0.70 |
| ▸ | JAK2 | O60674 | 13/20 | 0.70 |
| ▸ | TYK2 | P29597 | 13/20 | 0.70 |
| ▸ | JAK3 | P52333 | 12/20 | 0.70 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2575576 | 0.91 | JAK1 (0.85) | JAK1JAK2TYK2JAK3FLT3 | |
| SCHEMBL12172258 | 0.90 | JAK1 (0.71) | JAK1JAK2TYK2JAK3FLT3 | |
| SCHEMBL12172257 | 0.83 | JAK1 (0.65) | JAK1JAK2TYK2JAK3FLT3 | |
| SCHEMBL2574413 | 0.83 | JAK1 (1.00) | JAK1JAK2TYK2JAK3FLT3 | |
| SCHEMBL2571124 | 0.82 | JAK1 (0.75) | JAK1JAK2TYK2JAK3ABL1 | |
| SCHEMBL2571653 | 0.81 | JAK1 (0.84) | JAK1JAK2TYK2JAK3FLT3 | |
| SCHEMBL13547637 | 0.81 | JAK1 (0.66) | JAK1JAK2TYK2JAK3FLT3 | |
| SCHEMBL2574525 | 0.80 | JAK1 (0.70) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2574940 | 0.80 | JAK1 (0.83) | JAK1JAK2TYK2JAK3FLT3 | |
| SCHEMBL13547638 | 0.78 | JAK2 (0.67) | JAK1JAK2TYK2JAK3FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008031594-A1 | BENZOXAZOLES AND OXAZOLOPYRIDINES BEING USEFUL AS JANUS KINASES INHIBITORS | NOVARTIS AG (CH) | 2008-03-20 | — | — | WO | disclosed |