Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 13/20 | 0.45 |
| ▸ | JAK2 | O60674 | 12/20 | 0.45 |
| ▸ | TYK2 | P29597 | 10/20 | 0.45 |
| ▸ | JAK3 | P52333 | 8/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2571831 | 0.84 | JAK1 (0.58) | JAK1JAK2TYK2JAK3FLT3 | |
| SCHEMBL12172320 | 0.79 | JAK1 (0.71) | JAK1JAK2TYK2JAK3RPS6KA2 | |
| SCHEMBL12172231 | 0.78 | JAK1 (0.67) | JAK1JAK2TYK2JAK3BRAF | |
| SCHEMBL14280367 | 0.76 | JAK1 (0.65) | JAK1JAK2TYK2JAK3FLT3 | |
| SCHEMBL14280403 | 0.73 | JAK2 (0.47) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL20458123 | 0.71 | NPC1 (0.60) | FLT3NPSR1ALDH1A1 | |
| SCHEMBL2573644 | 0.71 | JAK1 (0.65) | JAK1JAK2TYK2JAK3FLT3 | |
| SCHEMBL2575954 | 0.71 | JAK2 (0.59) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2573586 | 0.69 | JAK2 (0.64) | JAK1JAK2TYK2JAK3ALDH1A1 | |
| SCHEMBL2571744 | 0.69 | TYK2 (0.70) | JAK1JAK2TYK2JAK3FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008031594-A1 | BENZOXAZOLES AND OXAZOLOPYRIDINES BEING USEFUL AS JANUS KINASES INHIBITORS | NOVARTIS AG (CH) | 2008-03-20 | — | — | WO | disclosed |