Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 11/20 | 0.68 |
| ▸ | TYK2 | P29597 | 10/20 | 0.68 |
| ▸ | JAK2 | O60674 | 10/20 | 0.68 |
| ▸ | JAK3 | P52333 | 9/20 | 0.68 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.44 |
| ▸ | FEN1 | P39748 | 4/20 | 0.44 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.41 |
| ▸ | WDR5 | P61964 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2572197 | 0.91 | JAK1 (0.68) | JAK1TYK2JAK2JAK3FLT3 | |
| SCHEMBL2571703 | 0.90 | JAK1 (0.84) | JAK1TYK2JAK2JAK3FLT3 | |
| SCHEMBL2571127 | 0.84 | JAK1 (0.64) | JAK1TYK2JAK2JAK3FLT3 | |
| SCHEMBL2571721 | 0.84 | JAK1 (0.63) | JAK1TYK2JAK2JAK3FLT3 | |
| SCHEMBL13547635 | 0.82 | JAK1 (0.72) | JAK1TYK2JAK2JAK3FLT3 | |
| SCHEMBL2574100 | 0.81 | JAK1 (1.00) | JAK1TYK2JAK2JAK3FLT3 | |
| SCHEMBL2574940 | 0.81 | JAK1 (0.83) | JAK1TYK2JAK2JAK3FLT3 | |
| SCHEMBL2573673 | 0.81 | JAK1 (0.79) | JAK1TYK2JAK2JAK3FLT3 | |
| SCHEMBL2574808 | 0.81 | JAK1 (0.69) | JAK1TYK2JAK2JAK3FLT3 | |
| SCHEMBL2574306 | 0.80 | JAK1 (0.88) | JAK1TYK2JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008031594-A1 | BENZOXAZOLES AND OXAZOLOPYRIDINES BEING USEFUL AS JANUS KINASES INHIBITORS | NOVARTIS AG (CH) | 2008-03-20 | — | — | WO | disclosed |