Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3936634 | 0.86 | AKR1C3 (0.51) | AKR1C3S1PR2CYP4F2CYP4A11NPC1 | |
| SCHEMBL1356271 | 0.78 | AKR1C3 (0.52) | AKR1C3AKR1C2CYP4F2CYP4A11NPC1 | |
| SCHEMBL1628254 | 0.77 | AKR1C3 (0.50) | AKR1C3AKR1C2PKMMAP4K4MAPT | |
| SCHEMBL15577951 | 0.76 | F10 (0.49) | AKR1C3NPSR1NPC1POLBCYP2C9 | |
| SCHEMBL29386478 | 0.76 | F10 (0.49) | AKR1C3NPSR1NPC1POLBCYP2C9 | |
| SCHEMBL15578353 | 0.76 | HDAC8 (0.51) | AKR1C3PKMNPC1POLBCYP2C9 | |
| SCHEMBL29386858 | 0.76 | HDAC8 (0.51) | AKR1C3PKMNPC1POLBCYP2C9 | |
| SCHEMBL2569034 | 0.75 | CYP4F2 (0.44) | AKR1C3AKR1C2PKMMAP4K4S1PR2 | |
| SCHEMBL9719786 | 0.73 | AKR1C3 (0.51) | AKR1C3NPC1POLBCYP2C9RAB9A | |
| SCHEMBL8783056 | 0.73 | AKR1C3 (0.71) | AKR1C3NPC1POLBCYP2C9RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080021085-A1 | METHOD OF REDUCING ABETA42 AND TREATING DISEASES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2008-01-24 | — | — | US | disclosed |
| US-20080021085-A1 | METHOD OF REDUCING ABETA42 AND TREATING DISEASES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021085-A1 | METHOD OF REDUCING ABETA42 AND TREATING DISEASES | BACE1, BACE2, APP | AKR1C3 561/4885AKR1C2 719/4885PKM 3948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.