Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGG1 | O15527 | 1/20 | 0.50 |
| ▸ | ACP1 | P24666 | 3/20 | 0.48 |
| ▸ | PDE5A | O76074 | 2/20 | 0.48 |
| ▸ | MERTK | Q12866 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CCR4 | P51679 | 1/20 | 0.46 |
| ▸ | WHR1 | P49842 | 1/20 | 0.45 |
| ▸ | GBA1 | P04062 | 3/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1427753 | 0.95 | KMT2A (0.49) | OGG1ACP1PDE5AMERTKKMT2A | |
| SCHEMBL2331315 | 0.88 | CHEK2 (0.47) | OGG1ACP1PDE5AMERTKKMT2A | |
| SCHEMBL9911806 | 0.87 | NSD2 (0.50) | KMT2AMEN1MAPTHTTGBA1 | |
| SCHEMBL17614452 | 0.83 | TLR7 (0.51) | ACP1PDE5AMERTKKMT2AMEN1 | |
| SCHEMBL14256445 | 0.83 | ACP1 (0.67) | OGG1ACP1PDE5AMERTKKMT2A | |
| SCHEMBL9911789 | 0.81 | NSD2 (0.53) | KMT2AMEN1MAPTHTTGBA1 | |
| SCHEMBL12988643 | 0.81 | ACP1 (0.68) | OGG1ACP1PDE5AMERTKKMT2A | |
| SCHEMBL17557550 | 0.81 | EHMT2 (0.47) | KMT2AMEN1HTTNSD2 | |
| SCHEMBL17544631 | 0.80 | ACP1 (0.65) | OGG1ACP1PDE5AMERTKKMT2A | |
| SCHEMBL23261502 | 0.79 | EHMT2 (0.62) | OGG1ACP1PDE5AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193203-B2 | Bicyclic compounds having activity at the CXCR4 receptor | ALLERGAN, INC. (US) | 2012-06-05 | — | — | US | disclosed |
| CN-102105463-A | Bicyclic compounds active on the CXCR4 receptor | ALLERGAN INC | 2011-06-22 | — | — | CN | disclosed |
| EP-2300456-A1 | BICYCLIC COMPOUNDS HAVING ACTIVITY AT THE CXCR4 RECEPTOR | Allergan, Inc. (US) | 2011-03-30 | — | — | EP | disclosed |
| US-20090312305-A1 | BICYCLIC COMPOUNDS HAVING ACTIVITY AT THE CXCR4 RECEPTOR | ALLERGAN, INC. (US) | 2009-12-17 | — | — | US | disclosed |
| WO-2009143058-A1 | BICYCLIC COMPOUNDS HAVING ACTIVITY AT THE CXCR4 RECEPTOR | ALLERGAN, INC. (US) | 2009-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312305-A1 | BICYCLIC COMPOUNDS HAVING ACTIVITY AT THE CXCR4 RECEPTOR | CXCR4, CXCR2, CXCL12 | OGG1 4094/4885ACP1 1225/4885PDE5A 1618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.