Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.45 |
| ▸ | SKP1 | P63208 | 1/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14283184 | 0.95 | BTK (0.43) | CKS1BSKP1SKP2SUV39H2BTK | |
| SCHEMBL3617867 | 0.87 | RET (0.45) | CKS1BSKP1SKP2CFTRPARP1 | |
| SCHEMBL14283324 | 0.83 | KIT (0.49) | CKS1BSKP1SKP2JAK2JAK1 | |
| SCHEMBL3612836 | 0.82 | JAK3 (0.47) | CKS1BSKP1SKP2RETSUV39H2 | |
| SCHEMBL14283157 | 0.80 | KIT (0.47) | CKS1BSKP1SKP2SUV39H2MAP4K4 | |
| SCHEMBL14283733 | 0.80 | CKS1B (0.36) | CKS1BSKP1SKP2CFTRPARP1 | |
| SCHEMBL14282914 | 0.79 | CDK2 (0.39) | KDRITGB2ICAM1ITGALJAK2 | |
| SCHEMBL2271966 | 0.78 | SUV39H2 (0.52) | CKS1BSKP1SKP2CFTRSUV39H2 | |
| SCHEMBL23173694 | 0.73 | CKS1B (0.51) | CKS1BSKP1SKP2CFTRPARP1 | |
| SCHEMBL529587 | 0.73 | CKS1B (0.56) | CKS1BSKP1SKP2CFTRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008034600-A1 | PYRROLE DERIVATIVES USEFUL FOR THE TREATMENT OF CYTOKINE-MEDIATED DISEASES | NOVARTIS AG (CH) | 2008-03-27 | — | — | WO | disclosed |