Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.39 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP4 | P49662 | 1/20 | 0.35 |
| ▸ | CASP5 | P51878 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14283774 | 0.90 | PIK3CA (0.41) | MAPTFEN1PRKD1PRKD2MYLK4 | |
| SCHEMBL3614067 | 0.87 | PRKD1 (0.48) | MAPTPRKD1PRKD2PRKD3ROCK2 | |
| SCHEMBL14283769 | 0.87 | CNR2 (0.45) | PRKD1PRKD2PRKD3MYLK4STK17A | |
| SCHEMBL3621763 | 0.86 | PRKD1 (0.46) | MAPTFEN1PRKD1PRKD2PRKD3 | |
| SCHEMBL13442018 | 0.85 | MAPT (0.38) | MAPTFEN1PRKD1PRKD2PRKD3 | |
| SCHEMBL13442301 | 0.85 | MAPT (0.38) | MAPTFEN1PRKD1PRKD2PRKD3 | |
| SCHEMBL13408197 | 0.85 | PIM1 (0.42) | MAPTPRKD1PRKD2PRKD3ROCK2 | |
| SCHEMBL13408193 | 0.85 | PIM1 (0.42) | MAPTPRKD1PRKD2PRKD3ROCK2 | |
| SCHEMBL13408196 | 0.84 | PIM1 (0.43) | MAPTFEN1PRKD1PRKD2ROCK2 | |
| SCHEMBL14283150 | 0.83 | CDC7 (0.36) | MAPTPRKD1PRKD2PRKD3ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008034600-A1 | PYRROLE DERIVATIVES USEFUL FOR THE TREATMENT OF CYTOKINE-MEDIATED DISEASES | NOVARTIS AG (CH) | 2008-03-27 | — | — | WO | disclosed |