Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SETD7 | Q8WTS6 | 6/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | HRH1 | P35367 | 6/20 | 0.43 |
| ▸ | PTAFR | P25105 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 4/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.40 |
| ▸ | DRD1 | P21728 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14559374 | 0.89 | SETD7 (0.54) | SETD7KCNH2TSHRHRH1PTAFR | |
| SCHEMBL11600017 | 0.85 | SETD7 (0.71) | SETD7KCNH2TSHRHRH1PTAFR | |
| SCHEMBL13888662 | 0.85 | KCNH2 (0.48) | SETD7KCNH2TSHRHRH1PTAFR | |
| SCHEMBL9718742 | 0.82 | KCNH2 (0.58) | SETD7KCNH2TSHRPTAFRTP53 | |
| SCHEMBL14307954 | 0.82 | SETD7 (0.48) | SETD7KCNH2TSHRHRH1PTAFR | |
| SCHEMBL11600344 | 0.81 | KCNH2 (0.55) | SETD7KCNH2TSHRHRH1PTAFR | |
| SCHEMBL9718775 | 0.81 | KCNH2 (0.52) | SETD7KCNH2TSHRHRH1PTAFR | |
| Hydrochloric Acid SCHEMBL9718801 | 0.80 | KCNH2 (0.52) | SETD7KCNH2TSHRHRH1PTAFR | |
| SCHEMBL9718791 | 0.80 | KCNH2 (0.56) | SETD7KCNH2TSHRHRH1PTAFR | |
| SCHEMBL9718766 | 0.80 | HRH1 (0.61) | SETD7KCNH2TSHRHRH1PTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7317026-B2 | Sleep disorders; side effect reduction ; antihistamine antagonist | HYPNION, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-7189757-B2 | Treatment of sleep disorders using CNS target modulators | HYPNION, INC. (US) | 2007-03-13 | — | — | US | disclosed |