Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 3/20 | 0.44 |
| ▸ | HTR4 | Q13639 | 6/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14287049 | 1.00 | SCNN1A (0.44) | SCNN1AHTR4ACHEMEN1ALDH1A1 | |
| SCHEMBL14287041 | 0.99 | SCNN1A (0.46) | SCNN1AHTR4ACHEMEN1ALDH1A1 | |
| SCHEMBL14287039 | 0.99 | SCNN1A (0.46) | SCNN1AHTR4ACHEMEN1ALDH1A1 | |
| SCHEMBL14287042 | 0.98 | SCNN1A (0.43) | SCNN1AHTR4ACHEMEN1ALDH1A1 | |
| SCHEMBL14287016 | 0.95 | SCNN1A (0.41) | SCNN1AHTR4ACHEMEN1ALDH1A1 | |
| SCHEMBL14189597 | 0.92 | CHRM1 (0.36) | SCNN1AALDH1A1CYP2D6 | |
| SCHEMBL14189643 | 0.91 | SCNN1A (0.37) | SCNN1AALDH1A1CYP2D6 | |
| SCHEMBL14189633 | 0.91 | CHRM1 (0.38) | SCNN1A | |
| SCHEMBL14189632 | 0.91 | CHRM1 (0.38) | SCNN1A | |
| SCHEMBL14287045 | 0.91 | SCNN1A (0.36) | SCNN1AHTR4MEN1ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7317013-B2 | Cyclic pyrazinoylguanidine sodium channel blockers | PARION SCIENCES, INC. (US) | 2008-01-08 | — | — | US | disclosed |