Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5092343 | 0.87 | KMT2A (0.67) | KMT2AMEN1CD274SMN1; SMN2RAB9A | |
| SCHEMBL3039929 | 0.86 | KMT2A (0.66) | KMT2AMEN1CD274SMN1; SMN2RAB9A | |
| SCHEMBL14197918 | 0.85 | KMT2A (0.64) | KMT2AMEN1CD274SMN1; SMN2RAB9A | |
| SCHEMBL5098986 | 0.84 | CD274 (0.66) | KMT2AMEN1CD274SMN1; SMN2RAB9A | |
| SCHEMBL5098402 | 0.84 | KMT2A (0.62) | KMT2AMEN1CD274SMN1; SMN2RAB9A | |
| SCHEMBL14287685 | 0.83 | HRH3 (0.65) | KMT2AHRH3 | |
| SCHEMBL14287671 | 0.82 | MEN1 (0.69) | KMT2AMEN1CD274HRH3ACHE | |
| SCHEMBL14287649 | 0.82 | SMN1; SMN2 (0.48) | KMT2AMEN1SMN1; SMN2HRH3RAB9A | |
| SCHEMBL5099092 | 0.82 | KMT2A (0.60) | KMT2AMEN1CD274SMN1; SMN2RAB9A | |
| SCHEMBL14287666 | 0.80 | HRH3 (0.54) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7314937-B2 | Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses | ELI LILLY AND COMPANY (US) | 2008-01-01 | — | — | US | disclosed |
| US-7314937-B2 | Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses | ELI LILLY AND COMPANY (US) | 2008-01-01 | — | — | US | disclosed |