Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | PRNP | P04156 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14310637 | 0.78 | CYP1A2 (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL18948584 | 0.75 | PDE10A (0.53) | PDE10ANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL17614927 | 0.74 | TYR (0.46) | PDE10ANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL20049185 | 0.72 | PDE10A (0.54) | PDE10ANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL889349 | 0.72 | NPC1 (0.43) | PDE10ANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL21195656 | 0.72 | NPC1 (0.43) | PDE10ANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL1102403 | 0.72 | CYP1A2 (0.59) | PDE10ANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL10122186 | 0.72 | NPC1 (0.43) | PDE10ANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL8347789 | 0.72 | PRNP (0.59) | RAB9ASMN1; SMN2ALDH1A1PRNPMEN1 | |
| SCHEMBL20032101 | 0.71 | CYP1A2 (0.33) | PDE10AKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080015190-A1 | Inhibitors of Histone Deacetylase | MERCK SHARP & DOHME CORP. | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015190-A1 | Inhibitors of Histone Deacetylase | HDAC5, HDAC1, HDAC4 | PDE10A 4311/4885NPC1 590/4885SCN4A 2858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.